KPV Tripeptide
Lys-Pro-Val Tripeptide C-Terminal Fragment of alpha-MSH
Pre-Clinical Overview & Monograph Profile
KPV is a biologically active synthetic tripeptide (Lys-Pro-Val) representing the anti-inflammatory C-terminal sequence of alpha-melanocyte-stimulating hormone (alpha-MSH). Evaluated across European academic laboratories for mucosal cytoprotection, antimicrobial defense, and nuclear translocation.
Verified UK Suppliers for KPV Tripeptide
| Supplier | Assay Purity | Reagent Format | Dispatch Location | Notes | Access |
|---|---|---|---|---|---|
| PharmaGrade Store | ≥99.1% (HPLC) | vial | United Kingdom (Royal Mail 24) | Lyophilized 5mg analytical reagent vials with certified HPLC purity chromatograms. | |
| Direct Peptides | ≥98.8% (HPLC) | vial | UK Hub & Europe | Solid-phase peptide synthesis catalog featuring laboratory research grade aliquots. |
Molecular Signaling Pathways
- 1Inhibits nuclear translocation of transcription factor NF-kappaB, attenuating pro-inflammatory cytokine expression (TNF-alpha, IL-8).
- 2Translocates directly into the cell nucleus via PepT1 transporter-mediated uptake to modulate genomic inflammation cascades.
- 3Suppresses leukocyte extravasation and local tissue edema in isolated epithelial and mucosal challenge models.
- 4Demonstrates direct antimicrobial action against Candida albicans and Staphylococcus aureus reference strains.
Laboratory Evaluation Guidelines
Extensively investigated across European pharmacological research for colonic epithelial barrier preservation, dermal wound remodeling, and mucosal cytoprotection. Formulated strictly for in vitro laboratory characterization under UK Schedule 1.
Receptor Affinity, SPPS Synthesis & Pharmacokinetics
Standardized chemical parameters, solid-phase synthesis criteria, and quantitative receptor affinity benchmarks for KPV Tripeptide.
- Suppression of IkappaB-alpha phosphorylation and degradation
- Inhibition of p65 RelA nuclear translocation
- Downregulation of IL-1beta, IL-6, and TNF-alpha transcription
Documented Biochemical Endpoints & Statistical Significance
| Study Design | Cohort (n) | Measured Biological Endpoint | Statistical Significance | NCBI Citation |
|---|---|---|---|---|
| In Vitro Assay | Colonic epithelial cell monolayers (Caco-2 / T84) | Epithelial resistance and cytokine attenuation under inflammatory challenge | p < 0.01 vs stimulated control | PMID 17698576 |
Indexed Scientific Literature
Curated Scientific Q&A for KPV Tripeptide
Authoritative pre-clinical, analytical, and statutory handling guidelines for laboratory researchers.
KPV Tripeptide (Lys-Pro-Val Tripeptide C-Terminal Fragment of alpha-MSH) is indexed in the CAS Registry under #67727-97-3. Its empirical molecular formula is C16H31N5O4 with a monoisotopic molecular weight of 357.45 g/mol. It is cataloged under the Tissue Repair & Angiogenesis research classification.
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